Sildenafil Citrate Information:
Sildenafil citrate, the active ingredient in Viagra, Kamagra, Silagra, Penegra, Caverta and various other ED medications, is the first oral agent that has become available to treat erectile dysfunction (ED) in men. Marketed under the name Viagra, Sildenafil received FDA market clearance in March 1998, and since that time it has been prescribed in brand and generic forms for over 18 million men worldwide. Sildenafil is a selective phosphodiesterase inhibitor type 5 (PDE5) in vascular smooth muscles of the corpus cavernosum Sildenafil has half-live of approximately 4 hours.
How does Sildenafil Citrate work?
Sildenafil citrate works by blocking a chemical that causes blood to flow out of the penis. Over 35% of men between the age of 40 and 60 reported that they have had at least one incidence of erectile dysfunction per month. When a man is sexually excited, Sildenafil Citrate increases smooth muscle relaxation, resulting in increased inflow of blood into the penis thus helps to achieve and maintain an erection. With more blood flowing in and less flowing out, the penis enlarges, resulting in an erection. When the sexual encounter is over, the erection goes away. Clinical studies show that Sildenafil citrate is effective in about 4 out of 5 men.
When Does It Start Working?
There have been reports of the drug taking effect in as little as 14 minutes. For most people, though, the drug takes effect in around half an hour and stays effective for up to 4 hours. Depending on the individuals, it is ready to work in about one hour in some cases. If you have had a fatty meal (i.e. a cheeseburger and fries), it may take a bit longer to take effect. Men over 65 years old will probably find that the drug does not last longer than 2 - 2.5 hours.
How Much Sildenafil Can I take?
Sildenafil Citrate doses range from 25 milligrams to 100 milligrams, depending on the drug s effect. The recommended starting dosage of Sildenafil citrate is the lowest, 25 mg in patients aged 18 - 65. In most cases the required dose is 50mg, and you can split a 100mg pill in two. You would be advised to use the lowest dose first and go up in dose if it doesn’t work for you. Like many medicines, your dosage may have to be adjusted if your initial dose does not produce the desired results. Do not take more than the recommended maximum dose (which is 100 mg per day). Your dose of sildenafil citrate depending on a number of factors, including:
- your age and conditions.
- how well it works for you.
- other medications you may be currently taking.
To avoid low blood pressure, do not take the 50-milligram or 100-milligram dose of Viagra within 4 hours of taking an alpha-blocking drug such as Doxazosin or Flomax.
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