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If you are allergic to Prednisolone, or if you have a fungal infection anywhere in your body. Prednisone is inactive in the body and, in order to be effective, first must be converted to Prednisolone by enzymes in the liver. As a serious illness, fever or infection, or if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Prednisone is inactive in the body and, in order to be effective, first must be converted to Prednisolone by enzymes in the liver.