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Antibiotics, although some side effects can be serious. Keflex is a cephalosporin antibiotic used to treat certain infections caused by susceptible bacteria sinusitis, respiratory infections, otitis media, skin and soft tissue infections, bone infections, genitourinary tract infections. Take Keflex at even intervals around the clock as prescribed by your doctor. Medications with known interactions with Keflex include blood thinners, probenecid, and Metformin. Patients taking other cephalosporin antibiotics can not take additional cephalosporin antibiotics as this is likely to result in an overdose. Patients with known allergy to the cephalosporin group of antibiotics. Cephalexin belongs to a class of antibiotics called cephalosporins.