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Celecoxib is a nonsteroidal anti-inflammatory drug that is used to treat arthritis, pain, menstrual cramps, and colonic polyps. Fluconazole increases the concentration of Celecoxib in the liver. This medicine. This medication helps you perform more of your normal daily activities. Celecoxib does not prevent the progression of either type of arthritis. Celecoxib is used for the relief of acute pain and the pain of menstrual cramps.