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How to take the drug based on the reason it is prescribed. Genital herpes outbreaks. If your immune system has been compromised you should discuss this with your doctor. If your immune system has been compromised you should discuss this with your doctor or healthcare provider that you are interested in finding out about daily therapy and obtaining a trial prescription of Valaciclovir, if appropriate. Valtrex can greatly decrease the length of time you experience an outbreak and may possibly reduce the number of your genital herpes outbreaks. Valaciclovir is most effective when taken within 24 hours of the start of symptoms. Valaciclovir disrupts the process by which the herpes virus. It can help reduce the number of outbreaks experienced in a year's time.